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We have immunological data and you have now clinical efficacy data. Everybody was asking the question: Where’s the clinical efficacy data? Now it has come out with the CDC MMWR this morning. So, we know it’s safe. We know that it is effective. So, my message and my final message — maybe the final message I give you from this podium — is that: Please, for your own safety, for that of your family, get your updated COVID-19 shot as soon as you’re eligible to protect yourself, your family, and your community. I urge you to visit Vaccines.gov to find a location where you can easily get an updated vaccine. And please do it as soon as possible.

This would not be the first time, if it happened, that a vaccine that looked good in initial safety actually made people worse. There was the history of the respiratory syncytial vaccine in children, which paradoxically made the children worse. One of the HIV vaccines that we tested some years ago actually made individuals more likely to get infected.

There's all of this concern about what's gain-of-function or what's not, with the implication that that research led to SARS-CoV-2, and COVID-19, which, George, unequivocally anybody that knows anything about viral biology and phylogeny of viruses know that it is molecularly impossible for those viruses that were worked on to turn into SARS-CoV-2 because they were distant enough molecularly that no matter what you did to them, they could never, ever become SARS-CoV-2

I was trying to let science guide our policy, but he was putting as much stock in anecdotal things that turned out not to be true as he was in what scientists like myself were saying. That caused unnecessary and uncomfortable conflict where I had to essentially correct what he was saying, and put me at great odds with his people.

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And the reason I'm concerned and my colleagues in public health are concerned also is that we very well might see a post-seasonal, in the sense of Christmas, New Year's, surge, and, as I have described it, as a surge upon a surge, because, if you look at the slope, the incline of cases that we have experienced as we have gone into the late fall and soon-to-be-early winter, it is really quite troubling. We are really at a very critical point. ... So I share the concern of President-elect Biden that as we get into the next few weeks, it might actually get worse.

...record numbers of cases, hospitalizations and deaths, the sweetness is the light at the end of the tunnel, which I can tell you — as we get into January, February, March and April — that light is going to get brighter and brighter, and the bitterness is going to be replaced by the sweetness

The answer is yes, a few, but one in particular. My youngest daughter’s boyfriend’s brother is a 32-year-old young man, athletic, healthy, who got COVID-19 and had one of the unusual complications of cardiomyopathy with an arrhythmia and died.

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I don't regret that. At that time, there was a paucity of equipment that our health care providers needed -- who put themselves daily in harm's way of taking care of people who are ill. We did not want to divert masks and PPE away from them, to be used by the people.