too much sugar, too much stress, too much sitting, too much pollution, too many pills, too many pesticides, too many screens, too little sleep, and too little micronutrients. These trends — with trillions of dollars behind them — are causing epidemic levels of mitochondrial dysfunction and underpowered, sick, inflamed bodies.
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He observed that when we build rockets we put over 10,000 sensors on them to understand the functioning of all parts of the spacecraft and to enable prediction of mechanical dysfunction and systems failure before it happens... Yet with human health, we adhere to an opposite paradigm. We wait for the human body to develop fulminant systems failure, which shows up as symptoms and meeting diagnostic thresholds for disease-specific biomarkers.
When our cells sense sustained danger, they divert resources to defense and alarm pathways instead of normal functions that generate sustainable health. Given this, no matter how pristine your dietary intake is, how much you’re moving, how much sunlight you’re getting, or how many hours of quality sleep you’re getting, if the cells are bathed in a stew of stress created by the way psychology translates to biochemistry (via hormones, neurotransmitters, inflammatory cytokines, and neurologic signals), all the other healthy choices will fall
Other Childhood Metabolic Conditions Epidemic levels of obesity, liver dysfunction, and brain dysfunction demonstrate a cellular energy epidemic. And our children’s small, not fully developed bodies are being set up to fail at an early age because our culture and daily lives have been co-opted by processed foods and the other factors that damage mitochondria and cellular energy production.
The second is that our food is being transported over large distances, causing degradation and damage to nutrients. The average distance that produce travels from farm to plate in the United States is approximately fifteen hundred miles. During this journey, some fruits and vegetables can lose up to 77 percent of their vitamin C content, a critical micronutrient for ATP production in the mitochondria and antioxidant activity in the cell. You may have thought that “eating local” or shopping from farmers’ markets is frivolous, but it is actually a critical step to ensure you are getting maximal helpful molecular information in the bites you take to build and instruct your body. The third is that most of our U.S. calorie consumption is ultra-processed foods, stripped of their nutrition. About 60 percent or more of the calories adults in the nation consume is ultra-processed garbage. You’re looking at just a fraction of that seventy tons meeting the cells’ functional needs.
Another way to practice mindfulness at any moment is to close your eyes and scan every sensation in your body: your heartbeat, your butt on the chair, any areas of warmth or cold, your toes on the ground, the air moving into your nose and lungs. Because this body scan forces you into the present moment, it takes you away from mental states of anxiety or stress.
Doctors have twice the rate of suicide as the general population. Based on my own experience with depression as a young surgeon, I think a contributor to this phenomenon is an insidious spiritual crisis about the efficacy of our work and a sense of being trapped in a system that is not working but seems too big to change or escape.
At the start of my residency, the Affordable Care Act (ACA) was passed and all doctors had to get up to speed on the Merit-Based Incentive Payment System (MIPS), a new program under the Quality Payment Program (QPP), where a physician would now receive substantial adjustments to payments from Medicare if they met specific quality-of-care criteria. One would think that “quality” and “merit” in medicine would mean that the patient was actually getting better. But when I dug deep through the MIPS website to find the specific quality metrics for each specialty, I was shocked to see that these quality criteria were primarily based on whether doctors prescribed drugs regularly or did more interventions. Yes, a government incentive program focused less on actual patient outcomes (i.e., Did the patient get healthier?) and more on whether doctors prescribed long-term pharmaceuticals.
Thermoneutrality”: A hallmark of modern industrial life is spending most of our time indoors at relatively consistent ambient temperatures, a concept we’ll refer to as thermoneutrality. Interestingly, experiencing swings in temperature is great for mitochondrial function, as cold stimulates the body to generate more warmth by increasing mitochondrial activity and stimulates more ATP generation and use. Heat exposure has been shown to activate heat shock proteins (HSPs) within cells, which can protect mitochondria from damage and help to maintain their function. HSPs can also stimulate the production of new mitochondria and improve their efficiency in producing ATP.
Authors and poets who address the human condition, mortality, eternity, and continuity with nature that I recommend are Mary Oliver, Pema Chödrön, Paramahansa Yogananda, Michael Pollan, Clarissa Pinkola Estés, Seneca, Marcus Aurelius, Robin Wall Kimmerer, Rumi, Lao-tzu, Khalil Gibran, Hafiz, Walt Whitman, W. S. Merwin, Thích Nhất Hạnh, Diane Ackerman, Alan Watts, Lewis Thomas, Ram Das, Rainer Maria Rilke, Deepak Chopra, and Wang Wei.
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On my mom’s final day of consciousness, she woke up weak and started to lose control of her speech. Later in the day, in a burst of energy, she urged us to take her to the place where she would soon be buried — a rustic forest grove overlooking fields and ocean, just three minutes from her house. We quickly drove her there and took her in a wheelchair to the natural burial site. My mom expressed amazement at the beauty of the ocean view and the trees she would soon be buried under, and we hugged as a family. She asked my dad to kneel beside her in the wheelchair and cupped his face in her hands. She looked at him and talked about how magical their life was together. On this small patch of earth with the Pacific Ocean behind them, they exchanged silent looks that expressed emotion and gratitude for each other that are impossible to fully convey in words. The awe and connection they shared as they exchanged their final embrace will forever be my definition of the meaning of life. “It’s just . . . so perfect and beautiful,” my mom burst out as she looked at her family embracing her at her final resting site. Minutes later, she lost consciousness. Two days later, surrounded by her family holding hands around her, she died. The final thirteen days I shared with my mom were the most meaningful of my life. If we had taken the advice of the medical system, they wouldn’t have happened.
Almonds Allspice, dried Amla berries, dried Apples Artichokes Asparagus Bay leaves, dried Basil, dried Black beans Black chokeberries Black elderberries Black pepper, dried Blackberries Black tea Blueberries Broccoli Capers Caraway seeds, dried Cayenne pepper, dried Celery leaves, dried Cherries Chives, dried Chili, dried Cinnamon bark, dried Clove, dried Cocoa powder Coffee beans Cumin, dried Curry powder Dandelion leaves, dried Dark chocolate Dill, fresh or dried Fennel leaves, dried Fennel seeds, dried Ginger, fresh or dried Green mint, dried Green olives, with stone Green tea Hazelnut Kalamata olives, with stone Lavender, dried Mustard seed, dried Nutmeg, dried Oregano, fresh or dried Paprika, dried Peaches Pecans Peppermint, dried Pistachios Plums Pomegranate, whole Red lettuce Red onion Rose flower, dried Rosemary, fresh or dried Saffron, dried Shallots Spinach Strawberries Tempeh Thyme, dried Turmeric, dried Vanilla seeds Walnuts White beans Wild marjoram leaves, dried
in the modern West, where — unlike many indigenous and Eastern cultures — we tend to be culturally avoidant of talking about death or having curiosity about it, leading it to be an existential fear for many. So many of the texts that have stood the test of time — spanning Rumi, Khalil Gibran, Hafiz, Marcus Aurelius, Yogananda, Seneca, Lao-tzu, Thích Nhất Hạnh, and more — implore us to examine death and trust that it is both natural and not to be feared.