The strange thing about the theory of evolution is that everyone thinks he understands it. But we do not. A biosphere, or an econosphere, self-consis… - Stuart Kauffman

If biologists have ignored self-organization, it is not because self-ordering is not pervasive and profound. It is because we biologists have yet to understand how to think about systems governed simultaneously by two sources of order. Yet who seeing the snowflake, who seeing simple lipid molecules cast adrift in water forming themselves into cell-like hollow lipid vesicles, who seeing the potential for the crystallization of life in swarms of reacting molecules, who seeing the stunning order for free in networks linking tens upon tens of thousands of variables, can fail to entertain a central thought: if ever we are to attain a final theory in biology, we will surely, surely have to understand the commingling of self-organization and selection. We will have to see that we are the natural expressions of a deeper order. Ultimately, we will discover in our creation myth that we are expected after all.

Francisco Varela is amazingly inventive, freewheeling, and creative. There's a lot of depth in what he and Humberto Maturana have said. Conversely, from the point of view of a tied-down molecular biologist, this is all airy-fairy, flaky stuff. Thus there's the mixed response. That part of me that's tough-minded and critical is questioning, but the other part of me has cottoned on to the recent stuff he's doing on self- representation in immune networks. I love it.

The onset of evolutionism brought with it the concept of branching phylogenies. The branching image, so clear and succinct, has come to underlie all our thinking about organisms and evolution.