In 2010... Nature asked specialists... to look ten years into the future, and I made this case... judging from the pattern of US history, we were due… - Peter Turchin

[I]nequality... at least in this model, is not a direct driver. It's a proxie for the direct drivers, which is immiseration and elite overproduction.

...[A]s a result ...the new elites, let's call them the elite aspirants... their numbers... begin to be so large that there is not enough power positions in... politics or in economics [e.g., corporations]... That's fixed, and as the numbers of elite aspirants vying for these positions increase, then first... the result... is intraelite competition, and secondly... the numbers of frustrated elite aspirants who are denied access to these positions begins to explode.

I claim that ... gives us a very good theoretical framework within which we can look at many different seemingly disparate trends in the United States... they suddenly start making sense... [D]eaths of despair ...I would argue that the opioid crisis is one of the manifestations of the immiseration, and in fact... go to Case and Deaton original book (project) on deaths of despair. They make this argument very eloquently. They give a lot of data, much better than I can do, so [the] opioid crisis is part of the bundle of reasons why immiserated population (people)... results in large swaths of [the] population who are falling... and many of them take the way out by either drugs and overdosing, or... suicide, or... alcoholism... or simply become careless and die in accidents... So this is clearly, and thanks to Anne Case and Angus Deaton for their excellent work, because here we can really see... The book is excellent. They talk about social immiseration, broken families and many other things. It really is a very coherent understanding of these problems.