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"All existing machines and memories use "direct addressing," which is to say that every word in the memory has a numerical address of its own that characterizes it and its position within the memory (the total aggregate of all hierarchic levels) uniquely."
John von Neumann (28 December 1903 – 8 February 1957) was a Hungarian-American-Jewish mathematician, physicist, inventor, computer scientist, and polymath. He made major contributions to a number of fields, including mathematics (foundations of mathematics, functional analysis, ergodic theory, geometry, topology, and numerical analysis), physics (quantum mechanics, hydrodynamics and quantum statistical mechanics), economics (game theory), computing (Von Neumann architecture, linear programming, self-replicating machines, stochastic computing), and statistics.
Biography information from Wikiquote
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He notes that the output of neurons is digital: an axon either fires or it doesn’t. This was far from obvious at the time, in that the output could have been an analog signal. The processing in the dendrites leading into a neuron and in the soma neuron cell body, however, are analog. He describes these calculations as a weighted sum of inputs with a threshold.