Are all the (measurable) dimensionless parameters that characterize the physical universe calculable in principle or are some merely determined by hi… - David Gross

Physics is always a gamble; it is a game of exploration. That’s the fun of it. We never know for sure what will happen. Sometimes, we theorists can anticipate, but nature is the final judge.

The universe has been expanding since the big bang, thus early on it was hot and dense. To trace the history of the universe we must understand the dynamics that operates when the universe was hot and particles were very energetic. Before the standard model we could not go back further than 200,000 years after the big bang. Today, especially since QCD simplifies at high energy, we can extrapolate to very eary times, where nucleons melt and quarks and gluons are liberated to form a quark-gluon plasma.

Why is space-time doomed? There are many reasons, among which: In string theory we can change the dimension of space-time by changing the strength of the string force. Thus, the so-called II-A string theory, which semi-classically describes closed strings moving in ten-dimensional flat space for very weak coupling is dual for strong coupling to a theory, called M-theory, that at low energies is described by eleven-dimensional supergravity. By increasing the string coupling we can grow an extra dimension. How can the spatial continuum be fundamental if the number of spatial dimensions can be so changed?