"Bonkie bit Garp!" Garp bit Bonkie - John Irving

It is amazing to me, now, how such wild imaginings and philosophies - inspired by a night charged with frights and calamities - made such perfectly good sense to Owen Meany and me, but good friends are nothing to each other if they are not supportive.

Almost everyone is dying to leave home, eventually; and almost everyone needs to.

I can't imagine what the first sentence is, I can't imagine where I want the reader to enter the story, if I don't know where the reader is going to leave the story. So once I know what the last thing the reader hears is, I can work my way backward, like following a roadmap in reverse.