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Anaerobic bacteria currently demonstrate increased resistance to antimicrobial agents, primarily by the production of beta-lactamase. A number of spe… - Sydney M. Finegold
" "Anaerobic bacteria currently demonstrate increased resistance to antimicrobial agents, primarily by the production of beta-lactamase. A number of species of Bacteroides, most notably those in the Bacteroides fragilis group, produce these enzymes. A few species of Fusobacterium and Clostridium produce beta-lactamase as well. Fortunately, this mechanism of resistance is readily overcome by administering beta-lactamase inhibitors coupled with a beta-lactam antibiotic that would otherwise be inactivated. Other types of resistance encountered in anaerobic bacteria include inactivating enzymes such as chloramphenicol acetyltransferase, plasmid-mediated transferable multiple-drug resistance, changes in porin molecules in the outer membrane of the bacterial cell, decreased uptake of drug by other mechanisms, changes in the target organs such as penicillin-binding proteins, and decreased reduction of the antibiotic to an active intermediate product. In many institutions, certain drugs such as cefoxitin, clindamycin, and piperacillin, which were previously active against almost all strains of B. fragilis, are now effective against only 70 to 85% of this group of anaerobes.
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About Sydney M. Finegold
Sydney "Sid" Martin Finegold (August 21, 1921 – September 17, 2018) was an American physician, medical school professor, and researcher in infectious diseases caused by anaerobic bacteria. He was elected in 1971 a Fellow of the American Academy for the Advancement of Science.
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Sydney Martin Finegold
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Additional quotes by Sydney M. Finegold
The bacteria typically described from biliary tract infection include Escherichia coli, Klebsiella, Enterobacter, and enterococci. It has also been recognized for some time that Clostridium perfringens may occasionally be involved in serious complications of biliary tract infection such as sepsis and emphysematous cholecystitis. Other anaerobes, including various Bacteroides and Fusobacterium sp, clostridia other than C perfringens, anaerobic cocci and streptococci, and Actinomyces have been reported from a variety of biliary tract infections, usually as single case reports ... More recently, several reports indicate that anaerobes, and especially B fragilis, may be more common in biliary tract infections than had been appreciated ... Anaerobes have been recovered in approximately 40% of such infections; B fragilis is the most common anaerobe encountered. Anaerobes may also be found, as aerobes are, in asymptomatic bactibilia.
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Much of the available data on the incidence of anaerobic infections is not reliable. Bacteriologic data without clinical correlation are not adequate, since the organisms are not necessarily significant. Similarly, clinical data with fragmentary bacteriological information are not ideal. In both types of papers, one often finds data on specimens cultured for anaerobes that clearly must have been contaminated with normal flora (for example, coughed sputum and voided urine). The exact specimen type and source is not always indicated or recognizable.
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