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" "Between the one who counts the facts, grouped according to their resemblance, in order to know what to believe regarding the value of therapeutic agents and him who does not count but always says "more or less frequent," there is the difference between truth and error, between something that is clear and truly scientific and something that is vague and without value—for what place is there in Science for that which is vague?
Pierre Charles Alexandre Louis (14 April 1787 – 22 August 1872) was a French physician known for inventing the "numerical method", a precursor to modern clinical trials, and for his work on infectious diseases and bloodletting.
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The objection made to the numerical method, to wit, the difficulty or impossibility of forming classes of similar facts, is alike applicable to all the methods that might be substituted; that it is impossible to appreciate each case with mathematical exactness, and it is precisely on this account that enumeration becomes necessary; by so doing, the errors, (which are inevitable,) being the same in two groups of patients subjected to different treatment, mutually compensate each other, and they may be disregarded without sensibly affecting the exactness of the results.