I was seized by the dreadful fear of going insane. I was taken to another world, another place, another time. My body seemed to be without sensation,… - Albert Hofmann

This self-experiment showed that LSD-25 behaved as a psychoactive substance with extraordinary properties and potency. There was to my knowledge no other known substance that evoked such profound psychic effects in such extremely low doses, that caused such dramatic changes in human consciousness and our experience of the inner and outer world. What seemed even more significant was that I could remember the experience of LSD inebriation in every detail. This could only mean that the conscious recording function was not interrupted, even in the climax of the LSD experience, despite the profound breakdown of the normal world view. For the entire duration of the experiment, I had even been aware of participating in an experiment, but despite this recognition of my condition, I could not, with every exertion of my will, shake off the LSD world. Everything was experienced as completely real, as alarming reality; alarming, because the picture of the other, familiar everyday reality was still fully preserved in the memory for comparison. Another surprising aspect of LSD was its ability to produce such a far-reaching, powerful state of inebriation without leaving a hangover. Quite the contrary, on the day after the LSD experiment I felt myself to be, as already described, in excellent physical and mental condition. I was aware that LSD, a new active compound with such properties, would have to be of use in pharmacology, in neurology, and especially in psychiatry, and that it would attract the interest of concerned specialists. But at that time I had no inkling that the new substance would also come to be used beyond medical science, as an inebriant in the drug scene. Since my self-experiment had revealed LSD in its terrifying, demonic aspect, the last thing I could have expected was that this substance could ever find application as anything approaching a pleasure drug.

The rapid rise of drug use, which had its beginning in this country about twenty years ago, was not, however, a consequence of the discovery of LSD, as superficial observers often declared. Rather it had deep-seated sociological causes: materialism, alienation from nature through industrialization and increasing urbanization, lack of satisfaction in professional employment in a mechanized, lifeless working world, ennui and purposelessness in a wealthy, saturated society, and lack of a religious, nurturing, and meaningful philosophical foundation of life.

I suddenly became strangely inebriated. The external world
became changed as in a dream. Objects appeared to gain inrelief;
they assumed unusual dimensions; and colors became more glowing.
Even self-perception and the sense of time were changed. When the
eyes were closed, colored pictures flashed past in a quickly changing
kaleidoscope. After a few hours, the not unpleasant inebriation,
which had been experienced whilst I was fully conscious, disappeared.
what had caused this condition?