Make more babies" because in "(t)wenty-five years ... the majority of the population is Hispanic. - John Gibson

Following the positive HIV test of adult actress Darren James on April 13, 2004, a new HIV scare led to a search for all potentially infected partners of the actor, as well as a two-month shut down of adult movie production in Los Angeles. Commenting on this on April 29, 2004, Gibson said that the actors "should not be surprised, considering what they do" and noted that "this was bound to happen to them sooner or later".

On the May 11 2006 broadcast of The Big Story, Gibson called for caucasians to have more children. His reasoning appeared to be in part to prevent Hispanics from ever being the racial majority in America. It is projected by the U.S. Census Bureau that persons of Hispanic descent will make up well over one-third of the U.S. population by the year 2050. The next day he said that he meant all Americans should have more children.

On the July 12, 2005, edition of Fox News's The Big Story, host John Gibson said that White House deputy chief of staff Karl Rove should be given "a medal" for outing covert CIA operative Valerie Plame, adding that Plame "should have been outed by somebody."