New diseases like syphilis seemed to call for new and "stronger" medicines; and this became one of the stock arguments for resort to the Paracelsian … - William Hardy McNeill

The Chinese language lacked terms capable of conveying Buddhist meanings; and not until the fifth century did a handful of scholars become sufficiently at home in both Chinese and Indian learning to be able to translate Buddhist texts into Chinese with a modicum of adequacy. ...the novel and initially alien outlook of the Indian faith had somehow to come to terms with the various strands already woven into Chinese culture, ranging... from Confucian and Taoist learning to local sub-literate peasant magic. ...while accommodating themselves to older Chinese expectations, Buddhist doctrines and practices simultaneously widened and redefined traditional Chinese sensibilities and aspirations.

Details of early domestications remain unclear. One must assume a process of mutual accommodation between humanity and various domesticable species. This involved rapid and sometimes far-reaching change in the biological character of domesticated plants and animals as a result of both accidental and deliberate selection for particular traits. Conversely, one can assume that a radical, if rarely deliberate, selection among human beings occurred as well. Individuals who refused to submit to laborious routines of farming, for instance, must often have failed to survive, and those who could not or would not save seed for next year's planting, and instead ate all they had, were quickly eliminated from communities that become dependent upon annual crops.

Painting responded to the plague-darkened vision of the human condition provoked by repeated exposure to sudden, inexplicable death. Tuscan painters reacted against Giotto's serenity, preferring sterner, hieratic portrayals of religious scenes and figures. The "Dance of Death" became a common theme for art; and several other macabre motifs entered the European repertory.