If the Krebs cycle is ordained by thermodynamics, then it should take place spontaneously in some suitably propitious envirnonment, even in the absen… - Nick Lane

For decades, biology has been dominated by information—the power of genes. ...[Y]et there is no difference in the information content of a living protozoon and one that died ...The difference between alive and dead lies in energy flow ...the ability of cells to continually regenerate themselves from simpler building blocks.

I read some of those ideas years ago, , and thought it was thrilling. Over recent years I don't really see the need for a kind of genetic intermediary between an RNA level of genetic replication and some other form of replicator. ...[T]here's no suggestion that it's there in biology. There's no suggestion that I know from geology that is capable of giving rise to more complex systems, or to having an organic takeover. It seems to add in a layer of unnecessary complexity. So I much prefer to get straight into organic chemistry, and straight into as we know it.

I would define complexity, not really as genetic complexity because if you take it purely as genetic complexity, E. coli... a single cell may have 4,000 genes but the metagenome, the pool of genes in E. coli around the place may be on the order to 30,000 or more... [T]hat's the level of complexity equivalent to the human genome, or even more complex than the human genome, but it's organized and structured in a different way. ...You might say that it's structured in a similar way to an ... but I think an ant colony has taken that level of Eusocial behavior a long way beyond anything you would see in E. coli. So I would define it as morphologically complex, meaning cells are larger and have a lot of stuff in them.