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" "In Newton's day the problem was to write something which was correct - he never had the problem of writing nonsense, but by the twentieth century we have a rich conceptual framework with relativity and quantum mechanics and so on. In this framework it's difficult to do things which are even internally coherent, much less correct. Actually, that's fortunate in the sense that it's one of the main tools we have in trying to make progress in physics. Physics has progressed to a domain where experiment is a little difficult... Nevertheless, the fact that we have a rich logical structure which constrains us a lot in terms of what is consistent, is one of the main reasons we are still able to make advances.
Edward Witten (born August 26, 1951) is an American theoretical physicist and professor at the Institute for Advanced Study, who is widely known as “the most brilliant physicist of his generation.” He is a leading researcher in string theory. In 1990, Witten won the Fields Medal, the most prestigious award in pure mathematics.
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Quantum mechanics... developed through some rather messy, complicated processes stimulated by experiment. While it's a very rich and wonderful theory, it doesn't quite have the conceptual foundation of general relativity. Our problem in physics is that everything is based on these two different theories and when we put them together we get nonsense.
It was found [in the 1970s], unexpectedly and without anyone really having a concept for it, that the rules of perturbation theory can be changed in a way that makes relativistic quantum gravity inevitable rather than impossible. The change is made by replacing point particles by strings. Then Feynman graphs are replaced by Riemann surfaces, which are smooth - unlike the graphs, which have singularities at interaction vertices. The Riemann surfaces can degenerate to graphs in many different ways. In field theory, the interactions occur at the vertices of a Feynman graph. By contrast, in string theory, the interaction is encoded globally, in the topology of a Riemann surface, any small piece of which is like any other. This is reminiscent of how non-linearities are encoded globally in twistor theory.