It was also the test that produced the most astounding observation of all. The left, talking brain didn’t seem to miss the right brain, and vice vers… - Michael S. Gazzaniga

Alzheimer’s disease, which is associated with the production and accumulation of amyloid-β in the brain. That means he has serious neural damage all over the brain. While for the past twenty years or so amyloid has been considered the “cause” of Alzheimer’s, there is recent evidence against that hypothesis, and others are being entertained.1 At any rate, the disease results in the slow destruction of the brain, commencing particularly with the loss of neurons in the entorhinal cortex and the hippocampus, resulting in short-term memory loss. The disease can become so debilitating that it can completely reshape Grandpa’s personality, transforming him from a lively and caring person into a listless shell of his former self. Yet, though he may not recognize me, he is still cognizant of social niceties and shakes my hand. He may wander off, but he will still feel fear when confused and lost, and anger when frustrated. His conscious experience of the world is brought to him through whatever operational neural circuitry continues to function, and as he loses function, it becomes more restricted. The contents of that conscious experience most likely are odd, very different from those of the normal brain or his past self. As a result, odd behavior follows.

I believe that things just happen in life, and pretty much after the fact, we make up a story to make it all seem rational. We all like simple stories that suggest a causal chain to life’s events. Yet randomness is ever present.

Schopenhauer’s framing kicked the problem of consciousness onto a much larger playing field. The mind, with all of its rational processes, is all very well but the “will,” the thing that gives us our “oomph,” is the key: “The will … again fills the consciousness through wishes, emotions, passions, and cares.”14 Today, the subconscious rumblings of the “will” are still unplumbed; only a few inroads have been made. As I write these words, enthusiasts for the artificial intelligence (AI) agenda, the goal of programming machines to think like humans, have completely avoided and ignored this aspect of mental life. That is why Yale’s David Gelernter, one of the leading computer scientists in the world, says the AI agenda will always fall short, explaining, “As it now exists, the field of AI doesn’t have anything that speaks to emotions and the physical body, so they just refuse to talk about it.” He asserts that the human mind includes feelings, along with data and thoughts, and each particular mind is a product of a particular person’s experiences, emotions, and memories hashed and rehashed over a lifetime: “The mind is in a particular body, and consciousness is the work of the whole body.” Putting it in computer lingo, he declares, “I can run an app on any device, but can I run someone else’s mind on your brain? Obviously not.”15