How the mind gears itself for its environment, she thought. And she recalled a Bene Gesserit axiom: “The mind can go either direction under stress — … - Frank Herbert

The mind can go either direction under stress — toward positive or toward negative:

Do you know what guerrillas often say? They claim that their rebellions are invulnerable to economic warfare because they have no economy, that they are parasitic on those they would overthrow. The fools merely fail to access the coin in which they must inevitably pay. The pattern is inexorable in its degenerative failures. You see it repeated in the systems of slavery, of welfare states, of caste-ridden religions, of socializing bureaucracies — in any system in which creates and maintains dependencies. Too long a parasite and you cannot exist without a host.

I realize that humans cannot bear very much reality. Most lives are a flight from selfhood. Most prefer the truths of the stable. You stick your heads into the stanchions and munch contentedly until you die. Others use you for their purposes. Not once do you live outside the stable to lift your head and be your own creature. Muad'Dib came to tell you about that. Without understanding his message, you cannot revere him!

There are problems in this universe for which there are no answers. Nothing. Nothing can be done.