The main inspirations for Powerpuff for me were the '66 Adam West Batman show, and Underdog. - Craig McCracken

[Question from the audience]: "If you could pick only one thing, what is the most important thing when it comes to creating and running your own series?"Craig McCracken: Characters. Great, likable characters that resonate with audiences. That's the most important thing. Concepts will get you to try out a show, to tune in to a show maybe, but concepts don't keep you watching over and over again. If you're not engaged with the characters and the personalities of the characters, you're not going to continue to watch that show.

When I was a kid I spent a lot of time playing with the artisticly rooted pieces of junk that George was selling me. My wife Lauren did the same the only difference was her junk was pink and had combable hair. Either way these toys were far from junk, in fact they were our lives. Everyday we would make up characters, worlds, and adventures for them. Lauren's My Little Pony world was no less valid than My Little Star Wars world.So imagine little Lauren's surprise when she heard there was going to be a cartoon of her favorite toy! Imagine her dissapointment when the cartoon didn't live up to the world she had created in her head. Maybe she wouldn't have been so upset if she realized that cartoon was only bad because it was produced by a bunch of dudes who couldn't believe they were working on My Little Pony, uggggh. Imagine if they let HER make it, she knows why girls like Pony, she knows what will make it fun and cool.Now imagine 30 years later in some crazy cosmic coincidence she actually does get a get a chance to finally bring that world she's had in her head since she was a little kid to life! Maybe just maybe if she can traverse the waters of notes, schedules, and executives she can finally inject a little a artistic integrity and creative vision into it and make a MLP that girls will actually really like.Heck I even like it now and I hated that lame Pony junk, it wasn't cool like my Star Wars junk.

What a lot of people have found out about Powerpuff Girls is initially they just think it's this little girl thing that's lame like My Little Pony or whatever. Then they watch it and they’re like "Wait a minute, this is really funny, and this is really good, and it's actually, you know, entertaining."