It was obvious that a substance with such fantastic effects on mental perception and on the experience of the outer and inner world would also arouse interest outside medical science, but I had not expected that LSD, with its unfathomably uncanny, profound effects, so unlike the character of a recreational drug, would ever find worldwide use as an inebriant. I had expected curiosity and interest on the part of artists outside of medicine — performers, painters, and writers — but not among people in general. After the scientific publications around the turn of the century on mescaline — which, as already mentioned, evokes psychic effects quite like those of LSD — the use of this compound remained confined to medicine and to experiments within artistic and literary circles. I had expected the same fate for LSD. And indeed, the first non-medicinal self-experiments with LSD were carried out by writers, painters, musicians, and other intellectuals.

Progress of human civilization in the area of defining human freedom is not made from the top down. No king, no parliament, no government ever extended to the people more rights than the people insisted upon. And I think we've come to a place with this psychedelic issue. And we have the gay community as a model, and all the other communities, the ethnic communities. We simply have to say, look, LSD has been around for fifty years now. We just celebrated the birthday. It ain't going away. We are not going away. We are not slack-jawed, dazed, glazed, unemployable psychotic creeps. We are pillars of society. You can't run your computers, your fashion houses, your publishing houses, your damn magazines, you can't do anything in culture without psychedelic people in key positions, and this is the great unspoken truth of American creativity. So I think it's basically time to just come out of the closet and go, "You know what, I'm stoned, and I'm proud."

We must always remember to thank the CIA and the Army for LSD, by the way. Everything is the opposite of what it is, isn't it? They brought out LSD to control people, and what they did was give us freedom. Sometimes it works in mysterious ways its wonders to perform. But it sure as hell performs them. If you look a the government report book on acid, the only ones who jumped out of windows because of it were the ones in the Army. I never knew anybody who jumped out of a window or killed themselves because of it.

LSD ... is one of the company of drugs now known as hallucinogens, and there is no doubt that in some people it produces exquisite visions. The big question is whether they are of the outer or inner world, whether in fact they heighten or deepen reality or fool the taker into believing that the kind of vision a madman sees is the real world that convention, habit, or sheer blunting of instinct hide from him.

LSD is a unique and powerful tool for the exploration of the human mind and human nature. Psychedelic experiences mediate access to deep realms of the psyche that have not yet been discovered and acknowledged by mainstream psychology and psychiatry. They also reveal new possibilities and mechanisms of therapeutic change and personality transformation.

LSD is a catalyst or amplifier of mental processes. If properly used it could become something like the microscope or telescope of psychiatry.

The rapid rise of drug use, which had its beginning in this country about twenty years ago, was not, however, a consequence of the discovery of LSD, as superficial observers often declared. Rather it had deep-seated sociological causes: materialism, alienation from nature through industrialization and increasing urbanization, lack of satisfaction in professional employment in a mechanized, lifeless working world, ennui and purposelessness in a wealthy, saturated society, and lack of a religious, nurturing, and meaningful philosophical foundation of life.

There were over 500 published studies that came out of ARC from 1935-1975, testing the limits of human tolerance for psychedelics, opiates, and amphetamines on prisoners.' Dr. Isbell's studies included dangerously high and prolonged doses of LSD on his subjects.

I've had cocaine, but I don't like it. The Beatles had lots of it in their day, but it's a dumb drug, because you have to have another one 20 minutes later. Your whole concentration goes on getting the next fix. Really, I find caffeine is easier to deal with. … A little mushroom or peyote is not beyond my scope, you know, maybe twice a year or something. You don't hear about it anymore, but people are still visiting the cosmos. We must always remember to thank the CIA and the Army for LSD. That's what people forget. … They invented LSD to control people and what they did was give us freedom. Sometimes it works in mysterious ways its wonders to perform.

A TV crew came over 10 years or so ago, on the anniversary of the discovery of LSD, and those guys were trying to push me towards saying how bad it was. They wanted me to talk about the dark underbelly of the drug culture. And I said, I'm not going to talk about that because I've never seen it, except in kids doing stuff that I don't know about and I'm not interested in... I've never taken crack and I've never taken ecstasy; none of us has. I don't want to take some strange drug and end up chewing my tongue for 12 hours.

I took some bad acid in November of 1965, and the after effect left me crazy and helpless for six months. My mind would drift into a place that was very electrical and crackly, filled with harsh, abrasive, low grade, cartoony, tawdry carnival visions. There was a nightmarish mechanical aspect to everyday life. My ego was so shattered, so fragmented that it didn't get in the way during what was the most unself-conscious period of my life. I was kind of on automatic pilot and was still constantly drawing. Most of my popular characters—Mr. Natural, Flaky Foont, Angelfood McSpade, Eggs Ackley, The Snoid, The Vulture Demonesses, Av' n' Gar, Shuman the Human, the Truckin' guys, Devil Girl—all suddenly appeared in the drawings in my sketchbook in this period, early 1966. Amazing! I was relieved when it was finally over, but I also immediately missed the egoless state of that strange interlude. LSD put me somewhere else. I wasn't sure where. All I know is, it was a strange place. Psychedelic drugs broke me out of my social programming. It was a good thing for me, traumatic though, and I may have been permanently damaged by the whole thing, I'm not sure. I see LSD as a positive, important life experience for me, but I certainly wouldn't recommend it to anyone else.

Deliberate provocation of mystical experience, particularly by LSD and related hallucinogens, in contrast to spontaneous visionary experiences, entails dangers that must not be underestimated. Practitioners must take into account the peculiar effects of these substances, namely their ability to influence our consciousness, the innermost essence of our being. The history of LSD to date amply demonstrates the catastrophic consequences that can ensue when its profound effect is misjudged and the substance is mistaken for a pleasure drug. Special internal and external advance preparations are required; with them, an LSD experiment can become a meaningful experience. Wrong and inappropriate use has caused LSD to become my problem child.

[Hallucinogenic drugs] now formed a circle, one could almost say a magic circle: the starting point had been the synthesis of lysergic acid amides, among them the naturally occurring ergot alkaloid ergobasin. This led to the synthesis of lysergic acid diethylamide, LSD. The hallucinogenic properties of LSD were the reason why the hallucinogenic magic mushroom teonanacatl found its way into my laboratory. THe work with teonanacatl, from which psilocybin and psilocin were isolated, proceeded to the investigation of another Mexican magic drug, ololiuhqui, in which hallucinogenic principles in the form of lysergic acid amides were again encountered, including ergobasin — with which the magic circle closed.

This self-experiment showed that LSD-25 behaved as a psychoactive substance with extraordinary properties and potency. There was to my knowledge no other known substance that evoked such profound psychic effects in such extremely low doses, that caused such dramatic changes in human consciousness and our experience of the inner and outer world. What seemed even more significant was that I could remember the experience of LSD inebriation in every detail. This could only mean that the conscious recording function was not interrupted, even in the climax of the LSD experience, despite the profound breakdown of the normal world view. For the entire duration of the experiment, I had even been aware of participating in an experiment, but despite this recognition of my condition, I could not, with every exertion of my will, shake off the LSD world. Everything was experienced as completely real, as alarming reality; alarming, because the picture of the other, familiar everyday reality was still fully preserved in the memory for comparison. Another surprising aspect of LSD was its ability to produce such a far-reaching, powerful state of inebriation without leaving a hangover. Quite the contrary, on the day after the LSD experiment I felt myself to be, as already described, in excellent physical and mental condition. I was aware that LSD, a new active compound with such properties, would have to be of use in pharmacology, in neurology, and especially in psychiatry, and that it would attract the interest of concerned specialists. But at that time I had no inkling that the new substance would also come to be used beyond medical science, as an inebriant in the drug scene. Since my self-experiment had revealed LSD in its terrifying, demonic aspect, the last thing I could have expected was that this substance could ever find application as anything approaching a pleasure drug.