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It has brought me the greatest sorrow you can imagine, because he was the most handsome little boy for his age that you could find. I feel his death even more than the loss of my own son [Fernando] because he was older and I knew him better and treated him as my own son. Nevertheless we must accept the will of God. May God forgive me, but I wish He had taken Christian instead of his son.

I found great enmities, personal passions, leagues and alliances among [my] officials, constantly turning everyone against the rest. Therefore, to see and ascertain the truth, I followed up the accusations against my fiscal officers made by their adversaries, and I examined their accounts from 1520 to 1530, that is for 10 years, to see if they had robbed me as some claimed. But, although some matters were not as satisfactory as they should have been, I found no fault… If there is a fault here, the principal cause is that everyone desires so many privileges to limit my sovereignty so that we would almost become colleagues and I would no longer be in charge.

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…Begging Your Holiness as earnestly as I can that you convene a general council with the urgency that the situation demands and that for optimal effect Your Holiness should write to other princes and potentates explaining why. Namely the need to create a united front against the expected Turkish attack and to prevent the heresies that have recently appeared from spreading further.

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These heretics have been so obstinate that no policy has worked or sufficed to get them to recognise their errors… I can see that if there were a way of forcing them we could justly move against them, but that is not the case now, nor do I currently have the means, because I am tired, alone and without help and there are so many of them that great force would be needed to overcome them. The true remedy is to convene a general council.

Since our Lord, who gave Fernando to us, wished to have him back, we must bend to His will and thank Him and beg Him to protect what is left. With great affection, my lady, I beg you to do this and to forget and leave behind all pain and grief.

Without the prior pacification of Italy, it could happen that as soon as I leave to succor you, Venice, Florence, Ferrara and Francesco Sforza will ally together, pull all their resources and invite the French to support them… Since I will need to take with me to Germany the army besieging Florence, we need a swift decision by His Holiness in this matter.

I am wholly decided and resolved to go in person to help my brother because his need is so great and the perils so extreme that it does not merely threaten him but places all Christendom at risk. I cannot and must not abandon him because of the office I hold and because of the obligations of fraternal friendship and also because he is such a good brother to me.

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(in regard to a counter attack against the Turks) “…because that is what I have wanted to do since I was a child and also to fulfill the responsibilities of my imperial title as chief protector and defender of our Christian religion. Therefore, despite the vast costs and distractions that I face at present on account of the war against the French, I have resolved to assemble a fleet as soon as I can to relieve Rhodes… ready to spare nothing to preserve, defend and deliver Rhodes from these tyrannical infidel enemies, devoting all our kingdom and dominions and our person if necessary.”