Christopher Reeve

[R]ecent experience has shown that even the most formidable lobbyists cannot derail legislation that has bipartisan and public support. The NRA was not successful in repealing the ban on assault weapons. The American public watched in disbelief as a dozen tobacco company executives testified at a Senate hearing that nicotine is not addictive and denied allegations that nicotine levels were being raised in cigarettes in order to increase addiction. Now we are witnessing the demise of the "Marlboro Man" and "Joe Camel". There are lawsuits in virtually every state by individuals demanding punitive damages against the tobacco companies. Just this week, thousands of government workers petitioned the President to ban smoking in government buildings. I sincerely doubt that the tobacco lobby will be able to stop this initiative. The religious right led by Pat Robertson, Pat Buchanan and the Christian Coalition tried twice unsuccessfully (in 1992 and 1996) to hijack the Republican Party and failed in both attempts. Here again, was a case when a supposedly powerful lobby did not succeed in promoting their agenda.

He was like an untied balloon that had been inflated and immediately released. I

So many of our dreams at first seem impossible, then they seem improbable, and then, when we summon the will, they soon become inevitable.

It gives me a moral compass. I often refer to Abe Lincoln, who said, "When I do good, I feel good. When I do bad, I feel bad. And that is my religion." I think we all have a little voice inside us that will guide us. It may be God, I don't know. But I think that if we shut out all the noise and clutter from our lives and listen to that voice, it will tell us the right thing to do. The Unitarian believes that God is good, and believes that God believes that man is good. Inherently. The Unitarian God is not a God of vengeance. And that is something I can appreciate.

For the record, I am a C-2 ventilator-dependent quadriplegic, which means that I am paralyzed from the shoulders down and unable to breathe on my own. For the last 7 years, I have not been able to eat, wash, go to the bathroom, or get dressed by myself. Some people are able to accept living with a severe disability. I am not one of them, and that is why I have a keen interest in research and am deeply disturbed by unreasonable attempts to block scientific progress. The fact that the House of Representatives banned cloning last year without careful deliberation makes the Senate debate a matter of great urgency.

I've always been a practical person, not one to waste time pursuing unrealistic goals or dreams. But today's dreams can soon become tomorrow's reality in biomedical research. Scientists studying how the brain's cells and chemicals develop, interact, and communicate with the rest of the body have been making strides in alleviating the suffering of patients with Alzheimer's, strokes, Parkinson's, and MS, as well as brain and spinal cord injuries. Only recently researchers have dis-covered that stem cells, which have the ability to adapt to any environmentt in the body, will probably be the most important factor in curing all of these conditions. For example, in order to repair the damaged spinal cord, stem cells can be extracted from the ventricles of the brain or from bone marrow and genetically engineered to become nerve tissue. Highly successful experiments on mice have shown that when these transformed stem cells are transferred into the site of the injury, they apparently understand that their mission is to replace the damaged circuitry, which causes significant functional recovery. Mice that have had their spinal cords completely transected have been able to walk confidently across tightropes and climb rope ladders after this treatment. You would think that these breakthroughs would be a cause for celebration throughout the disabled community. In scientific terms, we are very close to achieving the impossible; in practical terms, we have a long way to go. But it is very disheartening to hear a leading researcher announce, "give us a hundred million dollars and we can cure Parkinson's"; or, "if we raise 300 million dollars, we can find a cure for paralysis in 5 years instead of 15." The idea of spending 15 more years in a wheelchair being fed, dressed, and washed by others would be tolerable if the scientists were still in the dark and there was no hope of recovery. I think most disabled people would agree with me that it is very difficult to cope psychologically with the stark reality that our future now depends mostly on money.

[W]hile the budget for research is negotiated annually on Capitol Hill, Alzheimer's has crippled 4 million Americans. This disease alone costs our nation 100 billion dollars every year and this number is expected to rise dramatically as baby boomers continue to age. Parkinson's afflicts nearly half a million Americans and costs us at least 6 million a year. Another half million Americans suffer strokes each year, costing more than 30 million in medical treatment, rehabilitation, and long-term care. Diabetes afflicts nearly 16 million people. It is the leading cause of blindness, kidney disease, and limb amputations; and it costs our nation between 90 and 140 billion dollars a year.

If I can laugh, I can live.

I work with Dr. John McDonald at Washington University in St. Louis, and he is a very knowledgeable researcher on (Inaudible) stem cells, and a few years ago he said to me that in order to cure my particular condition, which is demyelination of nerves in a very small area of the spinal cord, right at the second cervical vertebrae, that if you imagine the rubber coating around a wire that allows conductivity of electricity, the same thing as with nerves, myelin is like that rubber coating. It's a fatty substance that if it comes off of the nerves, then signals do not go from the brain down to the spinal cord as required. However, it is possible, and he's demonstrated this as graphic(?) as possible, to re-myelinate. Now, a few years ago, he said, we would be willing to inject human embryonic stem cells into you and hope for the best. But hoping for the best is a very dangerous proposition for people with spinal cord injuries because our spinal cord injury affects every organ in the body, and the most serious side effect is that it severely compromises the immune system, so spinal cords patients, particularly with high level injuries like mine, are prone first to pneumonia, which I've had at least five times since my injury, many patients often die from that. Also, it compromises the cardiovascular system, compromises the digestive tract, the ... your whole bowel-bladder-sexual function, skin integrity and also bone density, so that osteoporosis becomes a very ... a very critical factor. So literally he said to me that the immunosuppression that would be required just to inject 30million human embryonic stem cells from an anonymous donor might kill me. And now, he would be unwilling as a doctor, because of the ethics involved that a doctor is ethically bound to give his patients the best possible treatment, he would not inject me with embryonic stemcells unless we go the other route, which is therapeutic cloning- taking an egg, removing the nucleus, taking DNA from my skin and deriving stem cells from that, which would be injected in a manner that would probably not be rejected by my immune system. So my future, and others would agree, many scientists would agree, my future, in terms of being able to recover will depend on some way of delivering stem cells without compromising my immune system and therapeutic cloning, which would use my DNA is the best hope.

If nucleus transplantation, aka therapeutic cloning, is banned, it will be a tremendous setback for science, and it will be indefinitely ... it will indefinitely prolong the suffering of hundreds of millions around the world, who are afflicted with wide variety of diseases and disabilities.

Today, human trials to defeat Parkinson's are underway in Sweden. In Israel, macrophages, scavenger cells that eat debris in the body, are being used to repair the damaged spinal cord within 2 weeks of injury. The first human subject was a 19-year-old girl from Colorado. Last week, the House of Lords in the United Kingdom passed legislation permitting research on cloned human embryos for the second time. Those are not rogue nations behaving irresponsibly. They are allies, no less moral than we are.

At first, dreams seem impossible, then improbable, and eventually inevitable.

When I met with the President in May of 1996, he stated that the ratio of research to clinical results is greater in this country than anywhere else in the world. Money spent on research brings practical results that absolutely justify the investment. Let's look at a few examples. NIH-sponsored research has resulted in the identification of genetic mutations that cause osteoporosis, Lou Gehrig's Disease, cystic fibrosis and Huntington's disease. Effective treatment for Acute Lymphoblastic Leukemia (ALL) has been developed and today nearly 80 percent of children diagnosed with ALL are alive and disease-free after 5 years. Because of research, the nature of medicine is changing. We are approaching disease at the cellular level. We are targeting problems earlier, more specifically, less intrusively, with greater success and fewer side effects. Advances in genetics will soon let us intervene in disease before symptoms appear.

Once you choose hope, anything's possible.

The insurance companies see this legislation as a tax. My question is: why is that unreasonable, particularly when the insurance companies would save so much money in the long run. Research will keep the American people healthier, resulting in fewer insurance claims. We tax oil companies and use the money to build and maintain highways. In New York state, if you win the lottery, you pay a significant tax which goes to a state fund for education. Most states have sales taxes which are a major source of revenue for a wide variety of programs and services that benefit the public. Why shouldn't insurance companies be asked to help solve the health care crisis in this country? Because of the advances to date, we can save millions of lives. Our challenge for the future is not just improving the quality of life of those we save, but finding the cures to prevent that suf-fering in the first place. Our scientists are on the threshold of major breakthroughs in almost every disease or condition that now cause so much hardship for people across the country and around the world. The insurance companies owe it to our families and our society to make a small sacrifice which can do so much good. I hope that this excellent piece of legislation which already has tremendous grassroots support will be enacted during this legislative session.