The ASDHQ might be efficient only in specific conditions that maximize truthful donor’s responses, requiring each blood service to create an environment of trust and transparency to increase donors’ compliance and improve the accuracy of the questionnaire.

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To reduce blood-borne HIV transmission, four main strategies need to be considered: more effective identification of blood donors at high risk of HIV infection, better laboratory screening for HIV, pathogen reduction of blood products and reduced blood utilization. Blood donor risk screening comes first in the overall process of collecting safe blood products.

We also determined the operational acceptability of the new ASDHQ by collecting qualitative data from the donors. We hypothesized that the ASDHQ questionnaire would reduce the rate of risk deferrals compared to historical data, increase HIV prevalence in deferred donors compared to HIV prevalence in accepted donors.