Many endocrine diseases of the body entail the production of 'crooked molecules'—molecules that are made in the wrong way by the cell. It is fairly common for a cancer cell to begin the production of a 'crooked' hormone that evokes dramatic changes in other body functions.

The neatly integrated paradigm for brain water... was derived from experiments done by Walter Dandy... Most brain scientists and brain physicians honour the Dandy paradigm as a navigator honours the North Star. ...yet new scientific evidence makes it difficult, if not impossible, to accept... It is a mismeme; the experimental facts no longer allow it to be 'true', and we need a paradigm switch.

It would be easier... if all animals spoke the same endocrine language, for then correlations made in the laboratory could be quickly moved to the bedside. Unfortunately, such is not the case. The hormone prolactin, for example, has at least seventy-eight different functions in seventy-eight different species

Somehow the same nurses, physicians, administrators and legal ombudsmen who prevented the study of the ventricular fluid of a patient with senile dementia, or obesity, or depression, or schizophrenia, because of the risks, will encourage diagnostic tests and therapy for patients with epilepsy that are far more destructive and immutable than the measurement and manipulation of hormones in the ventricle.