The belief that electricity, the fourth of the modern forces, is the stuff of thought has permeated brain science since the late 1700s. ...while the brain was regarded as 'dry', all other organs were conceived as 'wet'. Doubtless the study of brain electricity helped in understanding the internal circuits of the brain, but it solved few problems of brain disease.

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The neatly integrated paradigm for brain water... was derived from experiments done by Walter Dandy... Most brain scientists and brain physicians honour the Dandy paradigm as a navigator honours the North Star. ...yet new scientific evidence makes it difficult, if not impossible, to accept... It is a mismeme; the experimental facts no longer allow it to be 'true', and we need a paradigm switch.

Scientists have mastered the techniques of hormone analysis, measurement and manufacture. What is lacking is the correlation between a specific brain disease and a specific brain hormone. …these correlations can only come from a medical team of co-operating physicians.

Patients with uncontrolled epilepsy have an evaluation that usually begins with electrical studies of the surface of the brain. …A hole is drilled in the skull, and electrical measurements made from within the depths of the brain. A large flap of the skull is then lifted up, electrodes placed on the surface of the brain, and the flap sewn back into place so that more electrical studies can be done. The risks... are far greater than those associated with the ventricular taps needed for hormone studies. …If the team of doctors.. can help... areas of the brain that are sending 'bad' signals would be identified and removed... large portions of the brain might be taken away.