Even if there is only one possible unified theory, it is just a set of rules and equations. What is it that breathes fire into the equations and makes a universe for them to describe? The usual approach of science of constructing a mathematical model cannot answer the questions of why there should be a universe for the model to describe. Why does the universe go to all the bother of existing?

I believe the simplest explanation is, there is no God. No one created the universe and no one directs our fate. This leads me to a profound realization that there probably is no heaven and no afterlife either. We have this one life to appreciate the grand design of the universe and for that, I am extremely grateful.

Any physical theory is always provisional, in the sense that it is only a hypothesis: you can never prove it. No matter how many times the results of experiments agree with some theory, you can never be sure that the next time the result will not contradict the theory. On the other hand, you can disprove a theory by finding even a single observation that disagrees with the predictions of the theory. As philosopher of science Karl Popper has emphasized, a good theory is characterized by the fact that it makes a number of predictions that could in principle be disproved or falsified by observation. Each time new experiments are observed to agree with the predictions the theory survives, and our confidence in it is increased; but if ever a new observation is found to disagree, we have to abandon or modify the theory.

The rate of progress is so rapid that what one learns at school or university is always a bit out of date. Only a few people can keep up with the rapidly advancing frontier of knowledge, and they have to devote their whole time to it and specialize in a small area. The rest of the population has little idea of the advances that are being made
or the excitement they are generating.

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I think that when we die we return to dust. But there’s a sense in which we live on, in our influence, and in our genes that we pass on to our children. We have this one life to appreciate the grand design of the universe, and for that I am extremely grateful.

The subject of this book is the structure of space-time on length-scales from 10<sup>-13</sup>cm, the radius of an elementary particle, up to 10<sup>28</sup>cm, the radius of the universe. ...we base our treatment on Einstein's General Theory of Relativity. This theory leads to two remarkable predictions about the universe: first, that the final fate of massive stars is to collapse behind an event horizon to form a 'black hole' which will contain a singularity; and secondly, that there is a singularity in our past which constitutes, in some sense, a beginning to the universe.

The world has been changing even faster as people, devices and information are increasingly connected to each other. Computational power is growing and quantum computing is quickly being realised. This will revolutionise artificial intelligence with exponentially faster speeds. It will advance encryption. Quantum computers will change everything, even human biology. There is already one technique to edit DNA precisely, called CRISPR. The basis of this genome-editing technology is a bacterial defence system. It can accurately target and edit stretches of genetic code. The best intention of genetic manipulation is that modifying genes would allow scientists to treat genetic causes of disease by correcting gene mutations. There are, however, less noble possibilities for manipulating DNA. How far we can go with genetic engineering will become an increasingly urgent question. We can’t see the possibilities of curing motor neurone diseases — like my ALS — without also glimpsing its dangers.
Intelligence is characterised as the ability to adapt to change. Human intelligence is the result of generations of natural selection of those with the ability to adapt to changed circumstances. We must not fear change. We need to make it work to our advantage.
We all have a role to play in making sure that we, and the next generation, have not just the opportunity but the determination to engage fully with the study of science at an early level, so that we can go on to fulfil our potential and create a better world for the whole human race. We need to take learning beyond a theoretical discussion of how AI should be and to make sure we plan for how it can be. We all have the potential to push the boundaries of what is accepted, or expected, and to think big. We stand on the threshold of a brave new world. It is an exciting, if precarious, place to be, and we are the pioneers.
When we invented fire, we messed up repeatedly, then invented the fire extinguisher. With more powerful techno

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So remember to look up at the stars and not down at your feet. Try to make sense of what you see and wonder about what makes the universe exist. Be curious. And however difficult life may seem, there is always something you can do and succeed at. It matters that you don’t just give up. Unleash your imagination. Shape the future.