In my mind, there are few sins so egregious as extending life without health. This is important. It does not matter if we can extend lifespans if we … - David A. Sinclair

the evidence is irrefutable: if you believe climate change is a threat, you can't say that GMOs are, because the evidence that GMOs are safe is stronger than the evidence that climate change is occurring.

When the Sir2 enzyme is sitting on the mating-type genes, they remain silent and the cell continues to mate and reproduce. But when a DNA break occurs, Sir2 is recruited to the break to remove the acetyl tags from the histones at the DNA break. This bundles up the histones to prevent the frayed DNA from being chewed back and to help recruit other repair proteins. Once the DNA repair is complete, most of the Sir2 protein goes back to the mating-type genes to silence them and restore fertility. That is, unless there is another emergency, such as the massive genome instability that occurs when ERCs accumulate in the nucleoli of old yeast cells.

Yes, humans are separated from yeast by a billion years of evolution, but we still have a lot in common. S. cerevisiae shares some 70 percent of our genes.