Death is real. Death changes things. Everything else is filler, merely a message from our sponsor. - Michael Marshall Smith

My favourite memories involve the actual process of writing sketches - just a few guys lounging around in a room talking nonsense, until suddenly an idea would start to coalesce, and you'd start nudging it toward fruition. I've never laughed so much before or since. Also, there were those very, very few nights where you'd be on a stage and some strange contract developed between performers and audience, and everything you did was funny. That was magical - and a direct visceral experience that you never really get from writing prose.

My limited experience of such things told me that you get closest to the truth by not giving it advance warning that you're coming after it.

I don't think there are any irredeemable themes or tropes, just ones that are waiting for a fresh eye. Horror, science fiction, and fantasy deal with the eternal verities, the subjects that have always - and will always - speak most deeply about who we are. That's why they're the most fascinating genres, and why they're always there to be reinvented. At the very least you can ask, "This subject has been done to death now, so why are we so obsessed with it?" - and take a new angle from there.