The atomic theory was not generally accepted in the time of Democritus, largely because of its deterministic character, for it allows no chance, choi… - John Freely

Parmenides believed that all Being is what he called the One, and denied absolutely the possibility of change. He believed that the cosmos is full (i.e., no void), uncreated, eternal, indestructible, unchangeable, immobile sphere of being, and all sensory evidence to the contrary is illusory. One Parmenidean fragment stated, "Either a thing is or it is not," meaning that creation and destruction is impossible.

Empedocles tried to address the problem of change by saying that there is not one fundamental arche but four—earth, water, air, and fire—which generate all the material substances in nature by mixing together in various ways under the influence of forces he called Love and Strife.

Although many historians of the new millennium now take issue with the notion of a Scientific Revolution, it is generally agreed that Newton's work culminated the long development of European science, creating a synthesis that opened the way for the scientific culture of the modern age.