Warned by such evidences of their spiritual illness, believers profit by their humiliations. Robbed of their foolish confidence in the flesh, they ta… - John Calvin

Some think that He does not call her 'mother' but only 'woman' so as not to inflict a deeper wound of sorrow on her heart. I do not reject this; but another conjecture is no less probable, that Christ wanted to show that now that He has completed the course of human life, He puts off the condition in which He has lived and enters into the heavenly kingdom where He will rule over angels and men. For we know that Christ's custom always was to recall believers from looking at the flesh. This was especially necessary at His death.

Man doubtless has been made subject to vanity—man here been reduced to nothing—man is nothing. And yet how is he whom God exalts utterly nothing? How is he nothing to whom a divine heart has been given? Let us breathe again, brethren. Although we are nothing in our hearts, perhaps something of us may lurk in the heart of God.

The apostle denies that anyone actually knows Christ, who has not learned to put off the old man, corrupt with deceitful lusts, and to put on Christ.