Don't you know everything?" God smiled. "No, I outgrew that trick long ago. You can't imagine how boring it was. - Octavia E. Butler

Overall, the Pox has had the effect of an installment-plan World War III. In fact, there were several small, bloody shooting wars going on around the world during the Pox. These were stupid affairs—wastes of life and treasure. They were fought, ostensibly, to defend against vicious foreign enemies. All too often, they were actually fought because inadequate leaders did not know what else to do. Such leaders knew that they could depend on fear, suspicion, hatred, need, and greed to arouse patriotic support for war.
Amid all this, somehow, the United States of America suffered a major, nonmilitary defeat. It lost no important war, yet it did not survive the Pox. Perhaps it simply lost sight of what it once intended to be, then blundered aimlessly until it exhausted itself.

People have changed the climate of the world. Now they’re waiting for the old days to come back’

We keep falling into the same ditches, you know? I mean, we learn more and more about the physical universe, more about our own bodies, more technology, but somehow, down through history, we go on building empires of one kind or another, then destroying them in one way or another. We go on having stupid wars that we justify and get passionate about, but in the end, all they do is kill huge numbers of people, maim others, impoverish still more, spread disease and hunger, and set the stage for the next war. And when we look at all of that in history, we just shrug our shoulders and say, well, that’s the way things are. That’s the way things always have been.