In this situation, any feeling of gee-wiz exhilaration would be out of place. Consternation and fear would be closer to the mark; but the most approp… - Nick Bostrom

Searching for a cure for aging is not just a nice thing that we should perhaps one day get around to. It is an urgent, screaming moral imperative. The sooner we start a focused research program, the sooner we will get results. It matters if we get the cure in 25 years rather than in 24 years: a population greater than that of Canada would die as a result. In this matter, time equals life, at a rate of approximately 70 lives per minute. With the meter ticking at such a furious rate, we should stop faffing about.

Even a single missed crucial consideration could vitiate our most valiant efforts or render them as actively harmful as those of a soldier who is fighting on the wrong side. The search for crucial considerations (which must explore normative as well as descriptive issues) will often require crisscrossing the boundaries between different academic disciplines and other fields of knowledge. As there is no established methodology for how to go about this kind of research, difficult original thinking is necessary.

The singleton hypothesis is that Earth-originating intelligent life will (eventually) form a singleton. It is an open question whether the singleton hypothesis is true. My own opinion is that it is more likely true than not. Historically, we have seen an overarching trend towards the emergence of higher levels of social organization, from hunter-gatherer bands, to chiefdoms, city-states, nation states, and now multinational organizations, regional alliances, various international governance structures, and other aspects of globalization. Extrapolation of this trend points to the creation of a singleton.