If the only available genes produce rather large changes, disadvantageous one at a time, then it seems to me probable that evolution will not occur i… - J.B.S. Haldane

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If the only available genes produce rather large changes, disadvantageous one at a time, then it seems to me probable that evolution will not occur in a random mating population. In a self-fertilised or highly inbred species it may do so if several mutations useful in conjunction, but separately harmful, occur simultaneously. Such an event is rare, but must happen reasonably often in wheat...

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About J.B.S. Haldane

John Burdon Sanderson Haldane (5 November 1892 – 1 December 1964) was a British geneticist and evolutionary biologist.

Biography information from Wikiquote

Also Known As

Native Name: John Burdon Sanderson Haldane
Alternative Names: J. B. S. Haldane
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The change from one stable equilibrium to the other may take place as the result of the isolation of a small unrepresentative group of the population, a temporary change in the environment which alters the relative viability of different types, or in several other ways...

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Unaided common sense may indicate an equilibrium, but rarely, if ever, tells us whether it is stable. If much of the investigation here summarised has only proved the obvious, the obvious is worth proving when this can be done. And if the relative importance of selection and mutation is obvious, it has certainly not always been recognised as such.

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