I wasn't aware of Chargaff's rules when he said them, but the effect on me was quite electric because I realized immediately that if you had this sor… - Francis Crick

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I wasn't aware of Chargaff's rules when he said them, but the effect on me was quite electric because I realized immediately that if you had this sort of scheme that John Griffith was proposing, of adenine being paired with thymine, and guanine being paired with cytosine, then you should get Chargaff's rules. I was very excited, but I didn't actually tell Chargaff because it was something I was doing with John Griffith. ... This was very exciting, and we thought "ah ha!" and we realized - I mean what anyone who is familiar with the history of science ought to realize - that when you have one-to-one ratios, it means things go to together. And how on Earth no one pointed out this simple fact in those years, I don't know.

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About Francis Crick

Francis Harry Compton Crick (8 June 1916 – 28 July 2004) was a British physicist, molecular biologist and neuroscientist, most noted for being one of the co-discoverers of the structure of the DNA molecule in 1953.

Biography information from Wikiquote

Also Known As

Native Name: Francis Harry Compton Crick
Alternative Names: Francis H.C. Crick

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"The problem of the origin of life is, at bottom, a problem in organic chemistry — the chemistry of carbon compounds — but organic chemistry within an unusual framework. Living things, as we shall see, are specified in detail at the level of atoms and molecules, with incredible delicacy and precision. At the beginning it must have been molecules that evolved to form the first living system. Because life started on earth such a long time ago — perhaps as much as four billion years ago — it is very difficult for us to discover what the first living things were like. All living things on earth, without exception, are based on organic chemistry, and such chemicals are usually not stable over very long periods of time at the range of temperatures which exist on the earth's surface. The constant buffeting of thermal motion over hundreds of millions of years eventually disrupts the strong chemical bonds which hold the atoms of an organic molecule firmly together over shorter periods; over our own lifetime, for example. For this reason it is almost impossible to find "molecular fossils" from these very early times."

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