The principles of quantum mechanics are so contrary to ordinary intuition that they can best be motivated by taking a look at their prehistory. - Steven Weinberg

Our mistake is not that we take our theories too seriously, but that we do not take them seriously enough. It is always hard to realize that these numbers and equations we play with at our desks have something to do with the real world. ...The most important thing accomplished by the three-degree radiation background in 1965 was to force us to take seriously the idea that there was an early universe.

[I]n 1897 Thomson... detected a deflection... by electric forces between the rays and the electrified metal plates. ...due largely to the use of better vacuum pumps ...to where the effects of residual gas ...became negligible. (Some evidence for... deflection was [also] found... by Goldstein.) [D]eflection was toward the positively charged plate... away from the negatively charged one, confirming Perrin... that the rays carry negative electric charge.

So what happens to the effective field theories of electroweak, strong, and gravitational interactions at energies of order 10¹⁵–10¹⁸ GeV? I know of only two plausible alternatives. One possibility is that the theory remains a quantum field theory, but one in which the finite or infinite number of renormalized couplings do not run off to infinity with increasing energy, but hit a fixed point of the renormalizable group equations. ... The other possibility, which I have to admit is a priori more likely, is that at very high energy we will run into really new physics, not describable in terms of a quantum field theory. I think that by far the most likely possibility is that this will be something like a string theory.