Newton's achievements in optics alone would probably entitle him to a place on this list; however, they are considerably less important than his acco… - Tomas M. Milich

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Newton's achievements in optics alone would probably entitle him to a place on this list; however, they are considerably less important than his accomplishments in pure mathematics and mechanics. His major mathematical contribution was his invention of integral calculus, which he probably devised when he was twenty-three or twenty-four years old. That invention, the most important achievement of modern mathematics, is not merely the seed out of which much of modern mathematical theory has grown, it is also the essential tool without which most of the subsequent progress in modern science would have been impossible. Had Newton done nothing else, the invention of integral calculus by itself would have entitled him to a fairly high place on this list.