Aggregative consequentialist theories are threatened by infinitarian paralysis: they seem to imply that if the world is canonically infinite then it … - Nick Bostrom

Nature might be a great experimentalist, but one who would never pass muster with an ethics review board – contravening the Helsinki Declaration and every norm of moral decency, left, right, and center.

The cognitive functioning of a human brain depends on a delicate orchestration of many factors, especially during the critical stages of embryo development—and it is much more likely that this self-organizing structure, to be enhanced, needs to be carefully balanced, tuned, and cultivated rather than simply flooded with some extraneous potion.

[If] our actions have even the slightest effect on the probability of eventual colonization, this will outweigh their effect on when colonization takes place. For standard utilitarians, priority number one, two, three and four should consequently be to reduce existential risk. The utilitarian imperative “Maximize expected aggregate utility!” can be simplified to the maxim “Minimize existential risk!”