It is not easy to convey, unless one has experienced it, the dramatic feeling of sudden enlightenment that floods the mind when the right idea finall… - Francis Crick

My own prejudices are exactly the opposite of the functionalists’: “If you want to understand function, study structure,” I was supposed to have said in my molecular biology days. (I believe I was sailing at the time.) I think that one should approach these problems at all levels, as was done in molecular biology. Classical genetics is, after all, a black-box subject. The important thing was to combine it with biochemistry. In nature hybrid species are usually sterile, but in science the reverse is often true. Hybrid subjects are often astonishingly fertile, whereas if a scientific discipline remains too pure it usually wilts.

Both of us had decided, quite independently of each other, that the central problem in molecular biology was the chemical structure of the gene.

An honest man, armed with all the knowledge available to us now, could only state that in some sense, the origin of life appears at the moment to be almost a miracle, so many are the conditions which would have had to have been satisfied to get it going.