Big questions get big answers. - Francis Crick

It is not easy to convey, unless one has experienced it, the dramatic feeling of sudden enlightenment that floods the mind when the right idea finally clicks into place. One immediately sees how many previously puzzling facts are neatly explained by the new hypothesis. One could kick oneself for not having the idea earlier, it now seems so obvious. Yet before, everything was in a fog.

Both of us had decided, quite independently of each other, that the central problem in molecular biology was the chemical structure of the gene.

It is essential to understand our brains in some detail if we are to assess correctly our place in this vast and complicated universe we see all around us.