Biology doesn't know in advance what the end product will be; there's no Stuffit Compressor to convert a human being into a genome. But the genome it… - Gary F. Marcus
" "Biology doesn't know in advance what the end product will be; there's no Stuffit Compressor to convert a human being into a genome. But the genome itself is very much akin to a compression scheme, a terrifically efficient description of how to build something of great complexity-perhaps more efficient than anything yet developed in the labs of computer scientists (never mind the complexities of the brain, there are trillions of cells in the rest of the body, and they are all supervised by the same 30,000-gene genome). And although there is no counterpart in nature to a program that compresses a picture into a compact description, there is a natural counterpart to the program that decompresses the compressed encoding, and that's the cell. Genome in, organism out. Through the logic of gene expression, cells are self-regulating factories that translate genomes into biological structure.
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Additional quotes by Gary F. Marcus
"Sometimes guitar riffs get repeated over and over ("vamping," in the lingo of musicians), but generally there is a soloist proving variation that runs above that background, lest the song sound monotonous. Philip Glass's minimalist compositions (such as the soundtrack to 'Koyaanisqatsi') deviate from much of the classical music that preceded them, with much less obvious movement than, say, the Romantic-era compositions that his work seems to rebel against, yet his works, too, consist not only of extensive repetition but also of constant (though subtle) variation. Virtually every song you've ever heard consists of exactly that: themes that recur over and over, overlaid with variations."
What propels an embryo from one stage to the next-and makes one species different from another-is not a blueprint but rather an enormous autonomous library of the instructions contained within its genome. Each gene does double duty, specifying both a recipe for a protein and a set of regulatory conditions for when and where it should be built. Taken together suites of these IF-THEN genes give cells the power to act as parts of complicated improvisational orchestras. Like real musicians, what they play depends on both their own artistic impulses and what the other members of the orchestra are playing. As we will see in the next chapter, every bit of this process-from the Cellular Big 4 to the combination of regulatory cues-holds as much for development of the brain as it does for the body.
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