Not until the pioneer work of Rutherford and his colleagues was the possibility of nuclear reactions and transformations as sources of stellar energy… - Gerald James Whitrow

Einstein's pioneer application in 1917 of his newly developed general relativity to the problem of world-structure ushered in a new phase in the theoretical approach to the subject. Then, some seven years later, Hubble's discovery of Cepheid variables in the Andromeda nebula finally settled the long-debated question concerning this and similar nebulae in the Milky Way.

The models of Einstein and de Sitter are static solutions of Einstein's modified gravitational equations for a world-wide homogeneous system. They both involve a positive cosmological constant λ, determining the curvature of space. If this constant is zero, we obtain a third model in classical infinite Euclidean space. This model is empty, the space-time being that of Special Relativity.
It has been shown that these are the only possible static world models based on Einstein's theory. In 1922, Friedmann... broke new ground by investigating non-static solutions to Einstein's field equations, in which the radius of curvature of space varies with time. This Possibility had already been envisaged, in a general sense, by Clifford in the eighties.

Space-time is curved in the neighborhood of material masses, but it is not clear whether the presence of matter causes the curvature of space-time or whether this curvature is itself responsible for the existence of matter.