I advise you to look for a chance to break away, to find a subject you can make your own. That is where the quickest advances are likely to occur, as… - Edward O. Wilson

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I advise you to look for a chance to break away, to find a subject you can make your own. That is where the quickest advances are likely to occur, as measured by discoveries per investigator per year. Therein you have the best chance to become a leader and, as time passes, to gain growing freedom to set your own course.
If a subject is already receiving a great deal of attention, if it has a glamorous aura, if its practitioners are prizewinners who receive large grants, stay away from that subject. Listen to the news coming from the hubbub, learn how and why the subject became prominent, but in making your own long-term plans be aware it is already crowded with talented people. You would be a newcomer, a private amid bemedaled first sergeants and generals. Take a subject instead that interests you and looks promising, and where established experts are not yet conspicuously competing with one another, where few if any prizes and academy memberships have been given, and where the annals of research are not yet layered with superfluous data and mathematical models.