"You and I are real, Teddy, aren't we?" The bear's eyes regarded the boy unflinchingly. "You and I are real, David." It specialized in comfort. - Brian Aldiss

Most SF is about madness, or what is currently ruled to be madness; this is part of its attraction — it's always playing with how much the human mind can encompass.

Science fiction is for real, space opera is for fun.

It’d be kind of silly if we killed ourselves off after all this time. If we do, we’re stupider than the cave people and I don’t think we are. I think we’re just exactly as stupid and that’s pretty bright in the long run.