In a knot of eight crossings, which is about the average-size knot, there are 256 different 'over-and-under' arrangements possible... Make only one c… - Annie Proulx

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In a knot of eight crossings, which is about the average-size knot, there are 256 different 'over-and-under' arrangements possible... Make only one change in this 'over and under' sequence and either an entirely different knot is made or no knot at all may result.