Had Mother Nature been a real parent, she would have been in jail for child abuse and murder. - Nick Bostrom

[A]ssuming that the observable universe is void of extraterrestrial civilizations, then what hangs in the balance is at least 10,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000 human lives (though the true number is probably larger). If we represent all the happiness experienced during one entire such life with a single teardrop of joy, then the happiness of these souls could fill and refill the Earth’s oceans every second, and keep doing so for a hundred billion billion millennia. It is really important that we make sure these truly are tears of joy.

By anybody’s standards, there is a huge amount of unnecessary and undeserved suffering that is just bad and that we should get rid of.

The gap between a dumb and a clever person may appear large from an anthropocentric perspective, yet in a less parochial view the two have nearly indistinguishable minds.