Because as it turns out, exposing your body to less-than-comfortable temperatures is another very effective way to turn on your longevity genes. - David A. Sinclair

The first principle is that you must not fool yourself — and you are the easiest person to fool." R. P. Feynman,

to lose their identity and become cancerous. And geneticist Nir Barzilai spoke of genetic variants in long-lived humans and his belief that all aging-related diseases can be substantially prevented and human lives can be considerably extended with one relatively easy pharmaceutical intervention.

Most of my colleagues call these "longevity genes" because they have demonstrated the ability to extend both average and maximum lifespans in many organisms. But these genes don't just make life longer, they make it healthier, which is why they can also be thought of as "vitality genes."