It is the shortcomings of game theory (as originally formulated) which force the consideration of the role of ethics, of the dynamics of social struc… - Anatol Rapoport

At present game theory has, in my opinion, two important uses, neither of them related to games nor to conflict directly. First, game theory stimulates us to think about conflict in a novel way. Second, game theory leads to some genuine impasses, that is, to situations where its axiomatic base is shown to be insufficient for dealing even theoretically with certain types of conflict situations... Thus, the impact is made on our thinking process themselves, rather than on the actual content of our knowledge.

Our first objective in undertaking the experimental program described here has been to gain some understanding of what goes on in long sequences of plays of Prisoner's Dilemma. We have attempted to gain this understanding by postulating a system going through a sequence of states and by attempting to formulate some mathematical models from which the dynamics of the system could be deduced. Once such a model is found, its parameters, properly interpreted, become the key terms in the emerging psychological theory. This strategy can be deemed successful, if the parameters so discovered are independent of the process itself, if they suggest further investigation, and if the further investigations, in turn, lead to a more inclusive theory.

The predictions of physical theories for the most part concern situations where initial conditions can be precisely specified. If such initial conditions are not found in nature, they can be arranged. Such arrangements are considerably easier to realize with inanimate than with animate matter, because the properties of animate matter are much more sensitive to being tampered with than inanimate matter. In particular, living tissue in vitro may behave quite differently than in situ. Controlled biological experiments are, of course, possible, but they are more difficult and their scope is more limited than that of physical experiments. For this reason, biology has had to depend to a greater extent than physics on theories of larger speculative scope, in which reasoning by imaginative analogy plays a more important role.