We also knew that many other health-promoting molecules, and chemical derivatives of them, are produced in abundance by stressed plants; we get resve… - David A. Sinclair
" "We also knew that many other health-promoting molecules, and chemical derivatives of them, are produced in abundance by stressed plants; we get resveratrol from grapes, aspirin from willow bark, metformin from lilacs, epigallocatechin gallate from green tea, quercetin from fruits, and allicin from garlic. This, we believe, is evidence of xenohormesis — the idea that stressed plants produce chemicals for themselves that tell their cells to hunker down and survive.
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David Andrew Sinclair
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Dr. David Sinclair
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David A Sinclair
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David Sinclair
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After our species was almost driven to extinction 74,000 years ago, up until 1900, the human population grew at a rate amounting to a fraction of a percent each year as we expanded to all habitable regions on the planet, breeding with at least two other human species or subspecies. By 1930, thanks to sanitation and decreases in child-mother mortality, our species was increasing its numbers at 1 percent each year. And by 1970, due to immunization and improvements in food production globally, the rate was 2 percent each year. Two percent might not seem like a lot, but it added up fast. It took more than 120 years for our population to move from 1 billion to 2 billion, but after reaching that mark in 1927, it took just thirty-three more years to add another billion and then fourteen years to add another. This is how, at the end of the second decade of the twenty-first century, we came to have more than 7.7 billion people on our planet, and every year one additional person per square kilometer.
A study of more than 41,000 metformin users between the ages of 68 and 81 concluded that metformin reduced the likelihood of dementia, cardiovascular disease, cancer, frailty, and depression, and not by a small amount. In one group of already frail subjects, metformin use over the course of nine years reduced dementia by 4 percent, depression by 16 percent, cardiovascular disease by 19 percent, frailty by 24 percent, and cancer by 4 percent.22 In other studies, the protective power of metformin against cancer has been far greater than that.
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For Robin Marantz Henig, a columnist at the New York Times, the "bitter truth" about mortality came late in life, after she became a grandparent. "Beneath all the wonderful moments you may be lucky enough to share in and enjoy," she wrote, "your grandchild's life will be a long string of birthdays you will not live to see."3
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