Don't you feel ashamed when you let a machine tell you what to do? - Philip K. Dick

If practicality and morality are polarized and you must choose, you must do what you think is right, rather than what you think is practical.

There is certainly no hope left of getting away. And it isn't even terrible; it's possibly funny, if even that. It's embarrassing. That's all. A little embarrassing to realize that I no longer control my life, that the major decisions have already been made, long before I was conscious that any change was occurring.

In other words, the universe itself — and the Mind behind it — is insane. Therefore someone in touch with reality is, by definition, in touch with the insane: infused by the irrational.
In essence, Fat monitored his own mind and found it defective. He then, by the use of that mind, monitored outer reality, that which is called the macrocosm. He found it defective as well. As the Hermetic philosophers stipulated, the macrocosm and the microcosm mirror each other faithfully. Fat, using a defective instrument, swept out a defective subject, and from this sweep got back the report that everything was wrong.