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...[T]he sublimity and intrinsic dignity of the command in duty are so much the more evident, the less the subjective impulses favor it and the more they oppose it, without being able in the slightest degree to weaken the obligation of the law or to diminish its validity.
One brain’s blueprint may promote joy more readily than most; in another, pessimism reigns. Whether happiness infuses or eludes a person depends, in part, on the DNA he has chanced to receive.