Chinedum Peace Babalola (née Anyabuike) FAS, FAAS is a Nigerian Professor of Pharmaceutical chemistry and Pharmacokinetics. She teaches Pharmacy at the University of Ibadan, FAS, and FAAS while also being the first Vice Chancellor of Chrisland University, Nigeria
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Some drugs are expected to be taken after food, some are to be taken on an empty stomach. For drugs that should be taken in an empty stomach, studies have shown that when taken with food, there is an interaction which may reduce their effectiveness. Rather such drugs can be taken about 30 minutes before food.
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They should be able to clack the patient like a doctor to know medicines taken, how they are feeling, any need to change their medicine or dosage regime and so on. This is about individualised medicine. Nobody should die of drug reaction, if things work as they should. Handling over medicines, a pharmacy technician can do that. But information the patient needs about the drug should be provided by the pharmacist.
Work on quinine suppository has been on for so many years. Preliminary studies on the quinine suppository in rabbits indicated that it had antimalarial properties. However, the bioavailability is low. At the moment, one of our investigators is currently working in the USA on increasing its bioavailability to get an optimum product that will release the necessary level that they need. This will then be followed by more clinical trials.
Practice of combining antibiotic with anti-malarials is very common in Nigeria, are there possibilities of such a practice affecting the effectiveness of these drugs? From studies carried out many common antimalarials reduce the effectiveness of common antibiotics, thus promoting resistance in disease-causing germs to these antibiotics.
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All I can say is that I worked hard and as I was working hard, the titles kept coming. I became the first female pharmacy professor in UI when I was the director of General Studies and that was a whole lot of responsibilities because I was in charge of all the students, both regular and distant learning.
Also, one of my children also reacted to septrin syrup as a baby. At two years, when he was given Fansidar, an antimalarial drug that also contains Sulphur, he almost died. Because the tongue was red and the inside of the mouth was red, they suspected measles. Unfortunately, nobody suspected a reaction until much later that a consultant paediatrician doctor linked his condition with Stevens – Johnson syndrome. Based on this experience, I started a study on pharmaco-genetics, which entail looking at how gene can help predict a person’s reaction to a particular drug.
There are a lot of opportunities for women; the world is focusing on women. So, by now, I do not expect any woman or young girl to complain of not being given an opportunity because there are a lot of opportunities out there for all young girls and women in the world as we speak; all we need to do is to find opportunities and grab them.
The first study was on proguanil, a prophylactic antimalarial in healthy and sickle cell individuals. The study found that in persons with sickle cell, about one per cent of them breakdown the drug slowly while it was five per cent in healthy persons. This shows that there is genetic difference between the two groups of people.