Chinedum Peace Babalola (née Anyabuike) FAS, FAAS is a Nigerian Professor of Pharmaceutical chemistry and Pharmacokinetics. She teaches Pharmacy at the University of Ibadan, FAS, and FAAS while also being the first Vice Chancellor of Chrisland University, Nigeria
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Most allergic reactions occur within hours to two weeks after taking the medication and most people react to medications to which they have been exposed to in the past. This process is called “sensitisation.” However, rashes may develop up to six weeks after starting certain types of medications. Rarely, blisters and bleeding inside the skin or the inner surfaces of the intestines may occur. Unfortunately, if it is the life threatening anaphylaxis, it could be fatal. So, it is important to educate people about these possible reactions to drugs.
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Practice of combining antibiotic with anti-malarials is very common in Nigeria, are there possibilities of such a practice affecting the effectiveness of these drugs? From studies carried out many common antimalarials reduce the effectiveness of common antibiotics, thus promoting resistance in disease-causing germs to these antibiotics.
Work on quinine suppository has been on for so many years. Preliminary studies on the quinine suppository in rabbits indicated that it had antimalarial properties. However, the bioavailability is low. At the moment, one of our investigators is currently working in the USA on increasing its bioavailability to get an optimum product that will release the necessary level that they need. This will then be followed by more clinical trials.
All I can say is that I worked hard and as I was working hard, the titles kept coming. I became the first female pharmacy professor in UI when I was the director of General Studies and that was a whole lot of responsibilities because I was in charge of all the students, both regular and distant learning.
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Almost any drug can cause an adverse reaction. Reactions range from irritating or mild side effects such as nausea and vomiting to life-threatening anaphylaxis. Common symptoms of a drug reaction include hives, itching of the skin or eyes, skin rash, swelling of the lips, tongue, or face and wheezing.
Quinine is one of the oldest drugs in the pharmacopeia and during the time, chloroquine was failing, quinine came useful for the treatment of severe malaria until the ACT came on board. Being a drug that can be used to treat cerebral malaria, a life threatening form of malaria, only the quinine suppository would be useful in the rural areas where chances of giving it by intravenous injection may not be possible.
Also, one of my children also reacted to septrin syrup as a baby. At two years, when he was given Fansidar, an antimalarial drug that also contains Sulphur, he almost died. Because the tongue was red and the inside of the mouth was red, they suspected measles. Unfortunately, nobody suspected a reaction until much later that a consultant paediatrician doctor linked his condition with Stevens – Johnson syndrome. Based on this experience, I started a study on pharmaco-genetics, which entail looking at how gene can help predict a person’s reaction to a particular drug.